The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format.
When information is available in all sources, the first two are displayed as a priority. The source of the information is mentioned in the introductory sentence of the hazard statements. This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. If generated, an InChI string will also be generated and made available for searching. The molecular structure is based on structures generated from information available in ECHA’s databases. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. More information about CAS and the CAS registry can be found here. A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. CAS (Chemical Abstract Service) registry number The EC or list number is the primary substance identifier used by ECHA. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. More information about the EC Inventory can be found here. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). The EC Number is the numerical identifier for substances in the EC Inventory. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. The molecular structures of all compounds were confirmed by X-ray diffraction, and the cytotoxicity of Co( II) and Co( III) complexes towards cancer cell lines HCT116, HL-60 and normal cell line MRC-5 was studied.The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. The latter complex formed in a cobalt( II) acetate reaction with a hemisalen HL5 derived from oVP and 2-aminophenol.
#COBALT II CHLORIDE SERIES#
The following series of compounds was obtained: two similar tetrahedral molecular Co( II) complexes and, one trinuclear, mixed-ligand Co 3(Ac) 2( L4) 2( oVP) 2, one coordination polymer ∞ and finally one octahedral anionic Co( III) complex. The remaining reactions were performed using imines HL1–HL5 and cobalt( II) acetate Co(Ac) 2 in methanol or DMSO/acetonitrile resulting in forming a series of cobalt complexes. The conversion of these imines proceeded via self-cyclization to N-2′′-pyridyl-2,6-dioxo-9-aza-di-2′-methoxybenzo nonan or its methyl derivative as the major product.
It was observed that cobalt( II) chloride in dry acetonitrile catalyzes a transformation of HL1 and H元 instead of complex formation. The hemisalen ligands were synthesized from o-vanillin ( oVP) and diverse aminopyridines (compounds HL1–HL4) or aminophenol (compound HL5). Several molecular cobalt( II) complexes, one Co( II) coordination polymer and one ionic cobalt( III) complex with imine hemisalen ligands were synthesized.
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